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Filtered Search Results
Alkali Scientific Ethidium Bromide, Powder, 1 G
Ethidium Bromide (EtBr), 1g, is a widely used nucleic acid stain in molecular biology. When bound to DNA, it fluoresces under UV light, making it an essential tool for visualizing DNA in electrophoresis experiments. This powder form allows users to prepare a variety of EtBr solutions for different applications, depending on experimental requirements. It is used primarily in PCR, DNA sequencing, and other techniques where DNA separation and visualization are required. Ethidium Bromide remains one of the most common DNA stains due to its ease of use, sensitivity, and effectiveness in detecting nucleic acids in laboratory settings.
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Selleck Chemical LLC Dihydroethidium
Dihydroethidium (DHE HE Hydroethidine PD-MY 003) is a cell-permeable blue fluorogenic probe used for detecting intracellular superoxide radical anion
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Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 5mg, CAS: 104821-25-2.
Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer
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Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 10mg, CAS: 104821-25-2.
Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer
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Apexbio Technology LLC Chelerythrine Chloride 3895-92-9 5mg
Chelerythrine Chloride (CAS 3895-92-9) is a benzophenanthridine alkaloid widely utilized as a selective antagonist of protein kinase C (PKC) with an IC50 of 0 66 M It acts as a high-specificity inhibitor by targeting the kinase regulatory domain serving as a competitive inhibitor with respect to phosphate receptors and a non-competitive inhibitor toward ATP Chelerythrine also inhibits Bcl-xL inducing apoptosis in mouse embryonic fibroblasts (MEFs) with an IC50 of 1 1 M It activates the JNK1 and p38 pathways via MEKK1 and MKK4 contributing to its pro-apoptotic effects In cellular assays chelerythrine reduces cell viability (MTT IC50 2 6 M) and in animal studies promotes apoptosis through reactive oxygen species generation Its applications extend to research on kinase activity apoptosis antimicrobial activity and anti-inflammatory processes
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Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 250 MG
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Dimidium bromide is a biochemical reagent that can be used as a biological material or organic compound for various life science-related research applications.
- For research use only
- Stable under recommended storage conditions
- Store sealed, away from moisture and light
- Soluble in DMSO at 125 mg/mL
- Shipped at room temperature in continental US
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Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 ML
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ACT-1004-1239 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It is intended for research use only and not sold to patients.
- Inhibits human, dog, rat, mouse, guinea pig, and macaque CXCR7 with IC50s ranging from 0.6 to 3.2 nM.
- Promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels.
- Increases plasma CXCL12 concentration in vivo.
- Reduces disease severity in an EAE model.
- Increases myelination in a Cuprizone-induced demyelination model.
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Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 500 MG
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Dimidium bromide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
- Biochemical reagent
- Can be used as a biological material or organic compound
- For life science related research
- Identified uses are as laboratory chemicals and for the manufacture of substances
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![Medchemexpress LLC 3-piperidinecarboxamide, 1-(cyclopropylmethyl)-4-[[[5-(2,4-difluorophenyl)-3-isoxazolyl]carbonyl]am | 2178049-58-4 | 98.8% | 522.55 | C27H28F2N6O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221277.png-250.jpg)
Medchemexpress LLC 3-piperidinecarboxamide, 1-(cyclopropylmethyl)-4-[[[5-(2,4-difluorophenyl)-3-isoxazolyl]carbonyl]am | 2178049-58-4 | 98.8% | 522.55 | C27H28F2N6O3 | 5 MG
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ACT-1004-1239 is a potent, selective, orally active CXCR7 (ACKR3) antagonist supplied for research use. It shows nanomolar potency in biochemical assays and has demonstrated target engagement and pharmacological effects in preclinical models, including modulation of CXCL12/CXCL11 signaling and efficacy in rodent disease models. Supplied formats support both in vitro and in vivo study designs.
- Potent CXCR7 antagonism with reported IC50 of 3.2 nM.
- High purity suitable for research applications.
- Available as solid and 10 mM DMSO solution for convenient use.
- Appropriate for in vitro and in vivo pharmacology studies.
- For research use only; not for human or veterinary use.
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Medchemexpress LLC Propidium Iodide | 25535-16-4 | 99.69% | 100 MG
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Propidium Iodide (PI) is a nuclear staining agent that stains DNA. It is an analogue of ethidine bromide that emits red fluorescence when embedded in double-stranded DNA. PI cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. It has a fluorescence wavelength of 493/617 nm and 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis or necrosis, and is often used in flow cytometry analysis.
- Nuclear staining agent for DNA.
- Emits red fluorescence upon embedding in double-stranded DNA.
- Passes through damaged cell membranes to stain the nucleus.
- Fluorescence wavelength: 493/617 nm and 536/635 nm (after Mosaic with DNA).
- Commonly used in the detection of apoptosis or necrosis.
- Often used in flow cytometry analysis.
- Used in cell cycle and cell viability assays.
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AdipoGen Propidium Iodide Solution
Chemical. CAS 25535-16-4. Formula C27H34I2N4. MW 668.39. Synthetic. Most common red-fluorescent nuclear stain. Membrane impermeant and generally excluded from viable cells. It can easily penetrate dead or damaged cells and as such is commonly used for identifying cell viability in a population or as a counterstain in multicolor fluorescent techniques. It binds to DNA and RNA by intercalating between the bases. Suitable for use in fluorescence microscopy, confocal laser scanning microscopy, flow cytometry and fluorometry. Spectral data lambdaex=488-535nm, lambdaem=617nm.
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Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 50 MG
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ACT-1004-1239 is a potent, selective, and orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels. In animal models, it has been shown to reduce disease severity in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) and increase myelination in Cuprizone-induced demyelination models. This product is for research use only.
- Potent, selective, and orally active CXCR7 antagonist
- IC50 value of 3.2 nM
- Promotes oligodendrocyte precursor cell (OPC) differentiation
- Increases CXCL12 levels
- Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) in animal models
- Increases myelination in Cuprizone-induced demyelination models
- For research use only
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Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 5 G
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Dimidium bromide is a biochemical reagent suitable for use as a biological material or organic compound in life science-related research. It is intended for research use only and is not sold to patients.
- Molecular weight: 380.28
- Formula: C20H18BrN3
- Appearance: Solid
- Color: Pale purple to purple
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: RT, sealed storage, away from moisture and light. In solvent: -80°C for 1 year, -20°C for 6 months
- Solubility (in vitro): DMSO : 125 mg/mL (328.71 mM; requires ultrasonic; hygroscopic DMSO significantly impacts solubility, use newly opened DMSO)
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Selleck Chemical LLC Dihydroethidium
Dihydroethidium (DHE HE Hydroethidine PD-MY 003) is a cell-permeable blue fluorogenic probe used for detecting intracellular superoxide radical anion
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Medchemexpress LLC 3,6-Acridinediamine, N3,N3,N6,N6-tetramethyl- | 494-38-2 | 96.58% | 500 MG
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Acridine Orange base is a cell-permeable fluorescent dye. It stains various organisms such as bacteria, parasites, and viruses bright orange. When used under appropriate conditions (pH=3.5, Ex=460 nm), it can distinguish human cells in green for detection by fluorescence microscopy. This dye fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644). It can also be utilized in cell cycle assays.
- Cell-permeable fluorescent dye.
- Stains organisms bright orange.
- Distinguishes human cells in green under specific conditions.
- Fluoresces green when bound to dsDNA.
- Fluoresces red when bound to ssDNA or ssRNA.
- Can be used in cell cycle assays.
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